A new publication from the laboratory of Dr. Mahendran KR (Scientist, BRIC-RGCB) appeared in the journal "Small". The title of the manuscript is "A Dynamic Sugar-Selective Bacterial Nanopore for Targeted Antibiotic Transport".

A new publication from the laboratory of Dr. Dileep Vasudevan (Scientist, BRIC-RGCB) appeared in the journal "International Journal of Biological Macromolecules" and the title of the manuscript is "Cryo-EM structure provides insights into the unusual heptameric assembly of rice (Oryza sativa L.) ClpB1 AAA+ ATPase".

India unlocks its genetic code! The GenomeIndia Project, a landmark effort by 20 institutions, has mapped the nation’s genetic diversity—powering personalized medicine, inclusive public health, and future-ready research. BRIC-NIBMG is one of collaborators of this multi-institutional project and has actively engaged in sample collection, sequence data generation and data analysis.

In the recent EMBO reports paper from BRIC-NIBMG, we have shown that MYC enhancer RNA (eRNA) dynamically interacts with YEATS2 protein and recruits YEATS2-containing ATAC complex on MYC promoter to induce MYC gene transcription in pancreatic cancer.

BRIC-National Institute of Biomedical Genomics is a key member of Asian Immune Diversity Atlas (AIDA). The study sequenced over 1.2 million blood cells from 619 healthy individuals in six different Asian groups (Chinese, Japanese, Korean, Indian, Malay, Thai) across five countries (Singapore, Japan, Korea, Thailand and India). This initiative will provide a healthy baseline for characterizing cell state changes in diverse immune-related diseases including infectious and auto-immune diseases and thus form a foundation for precision medicine for Asian populations.

Research study by Dr. Raghavendra PB group at (BRIC-NIBMG) represents the first novel Tertiary Lymphoid Organs (TLO’s) inflammatory landscape in the diabetic foot wound ulcers. Study findings document immunophenotyping for TLO inflammatory stratification for DFU disease pathogenesis, progression. TLO study might be effective unveil to shed light and develop modality with the targeted antimicrobial therapies, immunomodulatory intervention strategies for DFU complications.

We are excited to share our new publication in the Journal of Cell Science, which reveals the presence of a subpopulation of P-bodies (PBs) and Stress Granules (SGs) at the ER-mitochondria contact sites (ERMCSs).

The parasites that cause leishmaniasis promote their own survival in the human host by manipulating a cellular process called ‘autophagy’ in cells of the host’s immune system, called macrophages. Dr. Shailza Singh and her student AT BRIC - National Centre for Cell Science developed mathematical models to simulate autophagy modulation in response to the parasite, and investigate how this influences their survival. The main findings of this research work are summarized below.

Researchers at BRIC - National Centre for Cell Science have shown that HuD becomes a master regulator of nerve cell apoptosis by regulating Msi2 levels in the cell. The study offers insights into the molecular players and pathways involved, suggesting potential therapeutic targets for addressing neurodegenerative conditions like Alzheimer's and Parkinson's diseases.

Fat Genes, Fat Wallets: Study from BRIC-NIBMG, in collaboration with JNU, discovers how Genetics and socio-demography matters in childhood obesity